Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates
Identifieur interne : 007075 ( Main/Exploration ); précédent : 007074; suivant : 007076Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates
Auteurs : Philip J. Boyne [États-Unis] ; Sergio Salina [États-Unis] ; Atsushi Nakamura [États-Unis] ; Franco Audia [États-Unis] ; Shahrokh Shabahang [États-Unis]Source :
- Cell and tissue banking [ 1389-9333 ] ; 2006.
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- Pascal (Inist)
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- topic : Personne âgée.
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Abstract
Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.
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Boyne</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1><s2>Loma Linda, CA 92450</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Salina, Sergio" sort="Salina, Sergio" uniqKey="Salina S" first="Sergio" last="Salina">Sergio Salina</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1><s2>Loma Linda, CA 92450</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nakamura, Atsushi" sort="Nakamura, Atsushi" uniqKey="Nakamura A" first="Atsushi" last="Nakamura">Atsushi Nakamura</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1><s2>Loma Linda, CA 92450</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Audia, Franco" sort="Audia, Franco" uniqKey="Audia F" first="Franco" last="Audia">Franco Audia</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1><s2>Loma Linda, CA 92450</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shabahang, Shahrokh" sort="Shabahang, Shahrokh" uniqKey="Shabahang S" first="Shahrokh" last="Shabahang">Shahrokh Shabahang</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1><s2>Loma Linda, CA 92450</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Cell and tissue banking</title><title level="j" type="abbreviated">Cell tissue bank.</title><idno type="ISSN">1389-9333</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cell and tissue banking</title><title level="j" type="abbreviated">Cell tissue bank.</title><idno type="ISSN">1389-9333</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Bone</term><term>Bone graft</term><term>Cell</term><term>Defect</term><term>Elderly</term><term>Induction</term><term>Nonhuman primate</term><term>Primates</term><term>Regeneration</term><term>Tissue</term><term>Tissue bank</term><term>Triggering</term><term>Type</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Os</term><term>Régénération</term><term>Induction</term><term>Déclenchement</term><term>Type</term><term>Défaut</term><term>Personne âgée</term><term>Primates</term><term>Animal</term><term>Banque tissu</term><term>Cellule</term><term>Tissu</term><term>Primate non humain</term><term>Greffe osseuse</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Boyne, Philip J" sort="Boyne, Philip J" uniqKey="Boyne P" first="Philip J." last="Boyne">Philip J. Boyne</name></region><name sortKey="Audia, Franco" sort="Audia, Franco" uniqKey="Audia F" first="Franco" last="Audia">Franco Audia</name><name sortKey="Nakamura, Atsushi" sort="Nakamura, Atsushi" uniqKey="Nakamura A" first="Atsushi" last="Nakamura">Atsushi Nakamura</name><name sortKey="Salina, Sergio" sort="Salina, Sergio" uniqKey="Salina S" first="Sergio" last="Salina">Sergio Salina</name><name sortKey="Shabahang, Shahrokh" sort="Shabahang, Shahrokh" uniqKey="Shabahang S" first="Shahrokh" last="Shabahang">Shahrokh Shabahang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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